不同抗消化性溃疡药防治非甾体类抗炎药致胃粘膜损伤的临床研究

Preventive Effect of Different Anti-peptic Ulcer Drugs on Gastric Mucosa Damage Induced by Nonsteroidal Anti-inflammatory Drugs

目的比较不同抗消化性溃疡药对长期服用非甾体类抗炎药患者胃粘膜损伤的临床疗效。方法对150例风湿性疾病患者,随机分为兰索拉唑组、法莫替丁组和铝碳酸镁组,在维持原来治疗方案继续服用NSAIDs的基础上,分别加服兰索拉唑15 mg,qd,法莫替丁20 mg,bid和铝碳酸镁2 g,bid。观察3个月时间后,对三组胃粘膜损伤及上消化道症状发生率进行比较。结果与兰索拉唑组比较,法莫替丁组和铝碳酸镁组胃粘膜损伤及上消化道症状发生率明显增多,差异有统计学意义(P<0.01)。结论对服用非甾体类抗炎药患者,兰索拉唑防治胃粘膜损伤效果显著,值得临床推广应用。

Objective To compare the preventive effects of different anti- peptic ulcer drugs on the gastric mucosa damage induced by nonsteroidal anti - inflammatory drugs. Methods One hundred and fifty outpatients with rheumatoid arthritis who received NSAIDs were randomly assigned into three groups to receive lansorazole 15 mg, PC, once daily; famotidine 20 mg, PC, twice daily, and hydrotalcite 2 g, PC, twice daily. The gastric mucosa damage status and upper gastrointestinal uncomfortable response of these 3 groups were monitored for 3 months and evaluated. Results Compared with the lansorazole group, the incidence of gastric mucosal damage and upper gastrointestinal uncomfortable response in the famotidine and hydrotalcite groups were significantly higher （P 〈 0.01 ）. Conclusions Lansorazole shows the most effective protection on gastric mucosa damage induced by nonsteroidat anti - inflammatory drugs, which is worth applying in general clinical practice.