不同类型病毒性肝炎患者血清Ⅳ型胶原检测及意义

The chang of serum collagen Ⅳ level and its significance in different types of patients with viral hepatitis

对各型病毒性肝炎患者检测血清Ⅳ型胶原，结果提示：急性黄疸型肝炎血清Ⅳ胶原含量与正常对照组无显著性差异。慢性病毒性肝炎伴早期肝硬化血清Ⅳ型胶原含量明显高于正常值，并随着病程的延长和病情的严重程度而增高。血清Ⅳ型胶原的测定及动态监测对肝纤维化的早期诊断、纤维化的进展和预后的判断具有重要的临床意义。

Serum collagen Ⅳ level of different types of patients with viral hepatitis wasdetermined. The results showed that there was no significant difference between the acutehepatitis and normal control. However, serum collagen Ⅳ level was elevated in patients withchroic hepaitis or cirrhosis. There was significan difference in serum collagen Ⅳ levelbetwen active and convalescent Periods for the patients with chronic hepatitis or cirrhosis. Theresults suggested that the measurement of serum collagen Ⅳ is very irnportant for earlydiagnsis. assessment of grade of hepaic fibrosis and prognsis of chronic hepatitis.