摘要
目的:评价中国同期放化疗中晚期鼻咽癌临床疗效和毒副反应。方法:应用Meta分析对中国同期放化疗治疗中晚期鼻咽癌临床试验进行综合评价。结果:治疗中晚期鼻咽癌,同期放化疗与常规放疗相比,减少远处转移率,其OR值为0.44(0.32-0.61);提高了1、3、5年生存率,其OR值分别为2.00(1.28-3.14)、2.31(1.83-2.92)、2.37(1.80-3.12)。白细胞减少、胃肠道反应、口腔黏膜反应的3/4度毒副反应率明显提高,分别是单纯放疗的10.27倍(2.38-44.32)、6.34倍(2.67-15.04)与2.06倍(1.28-3.31)。结论:同期放化疗治疗中晚期鼻咽癌临床疗效优于常规放射治疗,值得在临床上推广应用,但需注意毒副反应。
Objective: To evaluate the efficacy and toxicity of concurrent chemoradiotherapy for the treatment of locally advanced nasopharyngeal carcinoma (NPC) in Chinese population. Methods: Meta analysis method was used to analyze the comparative efficacy and toxicity of concurrent chemoradiotherapy versus radiotherapy alone for treatment of localy advanced nasopharyngeal carcinoma (NPC) in Chinese population. Results: Compared with radiotherapy alone, the results showed that the concurrent chemoradiotherapy decreased distant metastasis rate, and the OR was 0.44 (95%CI 0.32-0.61); the concurrent chemoradiotherapy increased lyear, 3year and 5year survival rate, and the OR was 2.00 (95%CI 1.28-3.14), 2.31 (95%CI 1. 83-2.92) and 2.37 (95%CI 1.80-3.12), respectively. Meanwhile, the concurrent chemoradiotherapy increased the risk for grade 3/4 leukemia 10.27 fold (95%CI 2.38-44.32), gastrointestinal effects 6.34 fold (95%CI 2.67-15.04) and oral mucositis 2.06 fold (95%CI 1.28-3.31), respectively. Conclusion: The clinical efficiency of concurrent chemoradiotherapy is superior to the radiotherapy alone. It is worth to generalize in clinics but should pay attention to its toxieity.
出处
《温州医学院学报》
CAS
2008年第3期237-240,共4页
Journal of Wenzhou Medical College
关键词
鼻咽肿瘤
放射疗法
化学疗法
META分析
nasopharyngeal neoplasms
radiotherapy
chemotherapy
Meta-analysis