部分脾动脉栓塞治疗肝硬化并脾功能亢进的临床研究

Clinical Study of Partial Splenic Embolization for Hypersplenla in Liver Cirrhosis

目的:探讨部分脾动脉栓塞术(PSE)治疗肝硬化门静脉高压及脾功能亢进的疗效及应用价值。方法:采用Seldinger技术行脾动脉栓塞术观察其外周血细胞变化、脾脏大小及门脉内径改变。结果:白细胞PSE后1～3天升高明显超过正常值,血小板1～3天后开始升高,血红蛋白术前后无明显变化,6～12月门脉宽度及脾脏显著性缩小,肝功能明显改善,食管静脉曲张程度减轻。结论:PSE是治疗肝硬化门脉高压及脾功能亢进的一种安全、有效、损伤小的治疗方法。

Objective：To investigate the therapeutic effect of partial spleen embolism（PSE）. Methods： 50 cases of patients suffering from posthepatitic cirrhosis hypersplenia were treated by PSE with Seldinger technique appplien. All patients were followed-up by 12 months. The data, including symptoms and signs, blood routine, findings by computed tomography, were collected before and after embolization for statistical analysis. Results： After operation leucocytes and thrombocytes both ascend within 3 days. All patients after PSE showed a good response on the improvement liver function and reduction of spenomegaly. Conclusion： Partial splenic embolization is helpful for relieving portal hypertension, diminishing the morbidity of massive hemorrhage in upper digestive tract, improving blood cell counts and immunity as well as living quality in patients with hypersplenism.