工作记忆中关系信息保持的事件相关电位

Event-related potentials of relational memory in target and delay phases of working memory

目的比较颜色、语义分别与其空间位置整合后在工作记忆保持阶段的事件相关电位(ERPs)时空模式特点。方法14名受试者分别从事工作记忆中颜色-位置和语义-位置整合的延迟匹配样本任务,同时记录其19通道的ERPs,行为数据采用配对t检验分析,ERPs数据利用配对t值的统计参数映像呈现。结果颜色-位置整合任务的反应时间显著短于语义-位置整合任务,且前者反应正确率显著高于后者。ERPs的t值统计参数映射显示两者显著差异主要出现在额中央回和顶部的大部分区域(200ms前后),双侧前额部和额部(260～320ms),左侧枕部(500～580ms)。结论汉语语义-位置的关系记忆的保持涉及更多脑区,特别是额区的效应最大提示工作记忆的目标保持阶段。

Objective To compare the spatiotemporal pattern of event-related potentials （ERPs） of relational memory retention between color-locatlon binding and semantics-location binding. Methods The ERPs of 19 channels were recorded from 14 healthy subjects while performing the two binding delayed-match-to-sample tasks, A paired-sample t test was used for analysis of both the behavioral performance and ERPs, and statistical parametric mapping （SPM） of the t values was applied to ERPs. Results Behavioral performances （reaction time and accuracy） in color-location binding were significant better than those of semantics-location binding. The SPM（t） of the ERPs showed significant effects in the middle frontal region and most areas of the parietal lobe （about 200 ms）, the bilateral prefrontal and frontal regions （260～320 ms）, and the left occipital region （500～580 ms）. Conclusion Retention of semantics-location relation involves more brain regions than that of color-location relation, and the largest effect occurs in the frontal region.