糖耐康对糖尿病KKA^y小鼠IL-6及TNF-α的影响

The Effects of Tangnaikang on IL-6 and TNF-α in Serum and Adipocytes of Diabetic KKA^y Mice

目的观察中药糖耐康对2型糖尿病KKA^y小鼠血清及脂肪组织IL-6和TNF-OC的影响。方法以发病周龄的KKA^y鼠为研究对象，加高脂饲料制备2型糖尿病模型，经灌胃糖耐康8周后，血糖仪试纸法测空腹血糖（FBG），ELISA法测血清及脂肪组织IL-6和TNF-OC的含量。结果糖耐康能很好地降低血清及脂肪的IL-6和TNF-α水平（P均〈0．05），高低剂量疗效相近。结论糖耐康可降低KKA^y小鼠血清和脂肪细胞的IL-6和TNF-OC水平：有助于降低血糖水平。

Objective To observe the effects of Tangnaikang on interleukin 6 （IL-6） and tumor necrosis factor-α （TNF-α） levels of Diabetic KKAy mice. Methods After diabetic KKAy mice were treated with Tangnaikang for 8 weeks, FBG was determined by glucose test-paper, IL-6 and TNF-αconcentrations in serum and adipocytes were determined by ELISA. Results IL-6 and TNF-α levels were reduced in serum and adipocytes of KKAy mice. Conclusion Tangnaikang can significantly reduce the levels of IL-6 and TNF-α in Diabetic KKAy mice, and the reduction of them can help to decrease FBG level.