系统性红斑狼疮与Th1、Th2细胞因子及IFIT4相关性研究

Study of the Correlation of Th1,Th2 and IFIT4 in Patients with Systemic Lupus Erythematosus

[目的]探讨系统性红斑狼疮(SLE)患者干扰素诱导蛋白4(IFIT4)与细胞因子Th1、Th2的相关性。[方法]对2006年8月至2007年12月山东省千佛山医院风湿免疫科门诊与病房的59例SLE患者进行检测,并与32名正常体检者对比。[结果]IFIT4 mRNA含量,SLE患者组高于对照组,SLE患者活动组高于非活动组(P<0.01);Th1(IFN-γ)细胞百分率和Th1/Th2型细胞比值,SLE患者组低于对照组,SLE患者活动组低于非活动组(P<0.01);SLE患者组的IFIT4 mRNA含量与SLEDAI积分呈显著正相关(P<0.01),与Th1/Th2比值呈负相关(P<0.01)。[结论]SLE患者的IFN诱导蛋白IFIT4可影响细胞因子的表达,IFIT4的表达水平和Th1/Th2比值均影响SLE发病和活动性。

[Objective]To investigate the Relation between Cytokine Th1 ,Th2 and interferon induced protein with tetratri-copeptide repeats 4 （IFIT4） in Patients with Systemic lupus erythematosus. [Methods]From August 2006 to December 2007,59 SLE patients in rheumatic and immunity department of Qianfoshan hospital were detected, and their results were compared with 32 people having general physical examination. [Results]The mRNA expression of IFIT4 was higher in SLE patients than that in control group,and higher in active group than that in non-active group （ P〈0.01） the percent of Th1 （IFN-7）, the ratio of the Th1/Th2 were obviously lower in SLE patients than that in control group, and lower in active group than that in non-active group （P〈0. 01） The mRNA expression of IFIT4 had positive correlation with SLEDAI integral in SLE patients （ P 〈0.01）, while the mRNA expression of IFIT4 had negative correlation with the ratio of the Th1/Th2（ P〈0.01）. [Conclusion]Interferon induced protein IFIT4 can affect the expression of cytokine in SLE patients,both the expression of IFIT4 lever and the ratio of the Th1/Th2 affected SLE and its activity.