RARβ和c—Jun在维生素A缺乏大鼠气道上皮鳞状化生中的表达和作用

The Role and Expression of c-Jun and retinoid acid receptor in the Airway Epithelium Squamous Metaplasia of Vitamin A Deficiency Rats

目的探讨气道上皮鳞状化生过程中RARβ和c—Jun的表达和作用。方法用维生素A缺乏的方法建立气道上皮鳞状化生的动物模型。免疫组化技术检测上皮RARβ和c—Jun蛋白表达。结果RARβ在实验组的表达均较对照组减低（P〈0．01），而c—Jnn在实验组表达高于对照组（P〈0．01）。结论在维生素A缺乏所致大鼠气道上皮鳞状化生过程中RARβ和c—Jun的表达呈反向变化，提示RARβ的表达减少，减弱了其对c—Jun的抑制，促进了上皮鳞状化生的形成。

Objective To explore the role and expression of RAR β and c-Jun in the airway epithelium squamous metaplasia of vitamin A deficiency （VAD） rats. Methods Establish squamous metaplasia model by feeding rats with Vitamin A deficiency diet. Immunohis-tochemistry is performed to investigate the expression of RAR β and c-Jun in epthelium.Results Comparing with control group, the expression of RAR β in VAD groups are statistically decreased （P〈0. 01）,but the expression of c-Jun are recreased. Conclusion The expression of c-Jun and RAR β are changed in the process of airway epithelium squamous metaplasia. The decrease of RAR β probably amplifies c-Jun exprssion and induces squamous metaplasia.