脑卒中后抑郁及其相关因素的临床研究

Clinical analysis of Post-stroke depression and the relative factors

目的探讨脑卒中后抑郁（PSD）的发生率、临床特点及其发病相关因素。方法对280例脑卒中患者进行汉密尔顿抑郁量表（HAMD）评分、神经功能缺损评分和残疾指数评分。对各相关因素进行统计分析。结果PSD总发生率40．3％，其中轻度抑郁25．7％，中度11．3％，重度3．2％；PSD临床表现主要为情绪低落、焦虑、绝望、睡眠障碍等；PSD发生与性别、卒中类型无关，而与神经功能缺损和残障程度、病程、病变部位等因素有关。结论PSD发生率较高，及时对有上述危险因素的患者行抑郁筛查，可望旱期发现PSD。

Objective To investigate the incidence and relative factors of Post-stroke Depression（PSD）,to study its clinical features. Methods 280 patients with stroke were accessed by 17-item Hamilton Depression Scales （HAMD） two weeks and three months after stroke. The neurological deficits scoresand the Oxford Handicap Scale were used to measure the patients at the same time. Analysis about the relative factors were carried out on the basis of these data. Results Among them, 113 cases were identified as depression. The minor, moderate and severe incidences were 25.7%,11.3%,3.2% respectively. The main manifestations of depression were anxiety , helplessness and insomnia. The important factors involved in PSD contained the degree of the neurological deficits and disabled, stroke course. It had no relation with sex, type of stroke. Conclusion The incidence of depression was high in post-stroke patients. To find out those patients with high risk factors and give them an examination about depression can diagnosis the PSD early.