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自身免疫T细胞对治疗脊髓损伤的实验研究及其可能机制 被引量：1

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作者 徐亮 陆佩华
机构地区 上海交通大学医学院神经生物学实验室
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2008年第6期567-569,共3页 Chinese Journal of Immunology
基金 国家重点基础研究发展规划项目(973)(2OO3CB5153O2) 上海市科技发展基金资助项目(02JC14014)资助
关键词 脊髓损伤 自身免疫性 治疗方法 T细胞 可能机制 实验研究 中枢神经系统损伤 神经元
分类号 R651.2 [医药卫生—外科学] R581.4 [医药卫生—内分泌]
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参考文献13

  • 1Hauben E,Nevo U, Yoles E et al. Autoimmune T cells as potential neuroprotective therapy for spinal cord injury[J]. Lancet, 2000; 355(9200) : 286-728.
  • 2Moalem G, Leibowitz-Amit R, Yoles E et al. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy [J] .Nat Med,1999;5(1):49-55.
  • 3Hauben E, Butovsky O, Nevo U et al. Passive or active immunization with myelin basic protein promotes recovery from spinal cord contusion[J]. J Neurosci, 2000; 20(17) :6421-6430.
  • 4Schwartz M.Protective autoimmunity as a T-cell response to central nervous system trauma: prospects for therapeutic vaccines[J]. Prog Neurobiol,2001 ;65(5) :489-496.
  • 5Schwartz M. Physiological approaches to neuroprotection, boosting of protective autoimmunity [ J ]. Surv Ophthalmol, 2001 ; 45 ( Suppl 3 ) : $256- S260; discussion S273-S276.
  • 6Schwartz M, Butovsky O, Bruck W et al. Microglial phenotype: is the commitment reversible? [ J]. Trends Neurosci, 2006; 29(2) : 68-74.
  • 7Kipnis J, Mizrahi T, Hauben E et al. Neuroprotective autoimmunity: naturally occurring CD4^+ CD25^+ regulatory T cells suppress the ability to withstand injury to the central nervous system [ J]. Proc Natl Acad Sci USA, 2002 ; 99(24) : 15620-15625.
  • 8Kipnis J, Cardon M, Avidan H et al. Dopamine, through the extraceUular signal-regulated kinase pathway, downregulates CD4^+ CD25^+ regulatory T-cell activity: implications for neuredegeneration[J]. J Neurosci,2004; 24(27) :6133-6143.
  • 9Schwartz M, Kipnis J. Protective autoimmunity and neuroprotection in inflammatory and noninflammatory neurodegenerative diseases[ J ]. J Neurol Sci, 2005 ; 233(1-2) : 163-166.
  • 10Jones T B,Basso D M,Sodhi A et al .Pathological CNS autoimmune disease triggered by traumatic spinal cord injury: implications for autoimmune vaccine therapy[ J] .J Neurosci,2002;22(7):2690-2700.

同被引文献70

  • 1Rol s A,Shechter R,Schwartz M. The bright side of the glial scar in CNS repair[J].Nature Reviews Neuroscience,2009,(03):235-241.
  • 2Cancil a PA,Breedy J,Breliner J. Expression of mRNA for glial fibrilary acidic protein after experimental cerebral injury[J].Neuropath Exp Ncurol,1992,(05):560-565.
  • 3Silver J,Mil er JH. Regeneration beyond the glial scar[J].Nat Rev Neumsci,2004,(02):146-156.doi:10.1038/nrn1326.
  • 4Haylock-Jacobs S,Keough MB,Lau L. Chondroitin sulphate proteoglycans:Extracel ular matrix proteins that regulate immunity of the central nervous system[J].Autoimmunity Reviews,2011,(12):766-772.
  • 5Moissonnier P,Reviron T,Ye JH. Motoneurons of the injured spinal cord of the adult dog can grow lengthy axons into an autologous peripheral nerve graft:a retrograde axonal tracing study[J].Spinal Cord:The Official Journal of the International Medical Society of Paraplegia,2006,(06):320-325.
  • 6Nishi RA,Liu H,Chu Y. Behavioral, histological,and ex vivo magnetic resonance imaging assessment of graded contusion spinal cord injury in mice[J].Journal of Neurotrauma,2007,(04):674-689.
  • 7Shechter R,Raposo C,London A. The Glial Scar-Monocyte Interplay:A Pivotal Resolution Phase in Spinal CordRepair[J].PLoS One,2011,(12):e27969.
  • 8Eng LF,Ghirn ikar RS. GFAP and astrogliosis[J].Brain Pathology,1994,(03):229-237.
  • 9Suzuki K,Okuno T,Yamamoto M. Semaphorin 7A initiates T-cel -mediated inflammatory responses through alpha1beta1 integrin[J].Nature,2007,(7136):680-684.
  • 10Zhang JX,Hu WW,Liu Z. Recent Advances in Treatm ent of Glial Scar induced Inhibition of Nerve Regeneration[J].ZHEJIANG DAXUE XUEBAO（YIXUE BAN）,2009,(06):639-664.doi:10.3785/j.issn.1008-9292.2009.06.015.

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中国免疫学杂志
2008年 第6期

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