摘要
造血干细胞(hematopoietic stem cell,HSC)具有自我更新功能和生成多个系列免疫造血细胞的多分化功能,终生维持机体造血。证据显示HSC会出现衰老,并与机体老龄化及各种损伤情况下出现造血系统应激能力下降有关。DNA损伤反应在诱导HSC衰老的各种机制中起重要作用。HSC发生衰老的机制的研究将对降低放化疗毒副作用,保护辐射等环境因素的损伤,了解白血病的干细胞起源及治疗逃逸机制提供有价值的科研资料,为药物筛选的靶点提供试验依据。
Lifelong blood cell production is achieved by the ca- pacity of hematopoietic stem cell（HSC） to differentiate and selfrenew. A growing body of evidence suggest that DNA damage induced HSC senescence may be the principal mechanism of aging and HSC exhaustion in response to the stress exposure. Understanding the mechanisms of HSC senescence will help to find new therapeutics that can ameliorate HSC injury induced by chemo-and radiotherapy, elucidate the molecular mechanisms whereby leukemia/cancer stem cell arise and evade cancer therapy by escaping senescence, and identify the novel molecular targets for intervention.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2008年第6期701-704,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No30770645)
