小儿脑瘫的遗传学研究进展

Genetics research progress of cerebral palsy

近年来脑瘫的病因在遗传、感染、早产等方面取得较大的进展。如基因位点的缺失、遗传性血栓的形成如Ⅴ因子Leiden突变、脑瘫患儿在数量上的性别差异、遗传多态性和早产/低出生体重关系、胎盘功能不足与胎儿宫内发育迟缓相关性、胎盘凋亡及凋亡相关基因等,从不同角度揭示遗传因素在脑性瘫痪发病中的作用。

The research on the etiology of cerebral palsy in many ways such as genetics, infection and premature delivery had made great progresses in recent years. Gene genetics such as genetic locus, gender different in number of cerebral palsy, genetic poly- morphism and premature delivery/low birth weight, placenta insufficiency and intrauterine growth retardation, apoptosis in the pla- centa and apoptosis - related genes had show the genetic factors in the invasion of cerebral palsy.