HR-HPV DNA检测与TCT检查的相关性研究及其在宫颈早期病变筛查中的应用

The study for relevance of HR-HPV DNA detecting and TCT testing & the application of it in screening for early cervical lesions

目的探讨TCT与HPV DNA检测结果的相关性,并评价该两种方法在宫颈早期病变筛查中的应用价值。方法对439名妇科门诊就诊者同时进行TCT检查和HPV DNA荧光定量PCR检测,并将两者的检测结果进行对比分析。结果439例样本中HPV DNA检测阳性者154例(35.1%),TCT结果阳性者163例(37.1%);两者均为阳性者65例(14.8%);经统计学分析,两种方法的检测结果不相关(P>0.05),TCT结果的异常程度与HR-HPV的感染数量亦无相关性(P>0.05)。结论该两种方法在宫颈早期病变的筛查中不能相互替代或相互验证;两种方法联合应用可使阳性检出率明显提高。

Objective ： To study the relevance of the test of thin prep liquid - based cytology and high - risk human papillomavirus DNA and to evaluate the value of them in screening for early cervical lesions. Mathods ： 439 cases of female patients were checked by TCT and HR - HPV DNA detection in the same time, and the results of the detections were compared. Results： Among 439 cases, there were 154 positive cases （35. ,1% ） for HR -HPV DNA detection and 163 positive cases （37.1%） for TCT test and there were 65 cases both positive （14. 8% ）. The results of the two mathods were no relevance by statistic analysis （ P 〉 0. 05）. Conclusion： The two mathods cannot be replaced or verified each other. The positive rate can be raised siginificately by combining the two mathods.