CMV血清学检测与孕期宫内感染的关系

Relationship between CMV serological detection and maternal intrauterine infection

目的探讨血清学方法检测巨细胞病毒(CMV)IgM、IgG对孕期宫内感染的诊断意义。方法取72例行人工流产术者的静脉血及绒毛、蜕膜。以酶联免疫吸附试验(ELISA)方法检测血清中CMV-IgG、IgM;以HE切片分析法检测绒毛、蜕膜病理改变。结果本组CMV-IgM(+)者40例中22例有CMV典型病理改变,单纯CMV-IgG(+)者病理改变比较轻微。结论仅凭CMV-IgM、CMV-IgG等血清学试验来判断CMV宫内感染有失准确。

Objective： To evaluate serological tests on cytomegalovirus （CMV） IgM and IgG in intrauterine infection of pregnant women. Methods ： Venous blood , chorionic villi and deciduas from 72 subjects in artificial abortion were collected . Serum CMV - IgG and IgM were tested by ELISA methods. Pathological changes of chorionic villi and deciduas were detected by Hema - toxylin and Eosin （HE） analysis. Results： 22 of 40 have representative pathological changes of CMV in CMV- IgM （ ＋ ） group. Patients in only CMV - IgG （ ＋ ） group have hardly pathological changes. Conclusion： It is not exact to diagnosis intrauterine infection of CMV only by serological tests of CMV - IgM, CMV - IgG.