控释前列腺素E2栓剂与催产素引产效果评价

Induction of labour with prostaglandin E2 and oxytocin in trimester pregnancy

目的评价控释前列腺素E2(商品名:普贝生)栓剂引产的安全性及有效性。方法病例对照研究的方法,选择114例孕妇,其中54例采用小剂量催产素引产,60例采用普贝生,通过比较两组用药前后的宫颈Bishop评分、临产时间、第一产程时间、第二产程时间来评价其引产的有效性;通过比较两组间出现高张宫缩、过频宫缩、宫缩乏力、新生儿窒息率、胎儿窘迫发生率、剖宫产率及自然分娩率等因素来评价其引产的安全性。采用SPSS软件处理所得数据。结果普贝生组促宫颈成熟作用明显高于催产素组(显效率94.2%∶11.1%);普贝生组临产时间(912±334分∶2309±1042分;)、第一产程时间(307±94分∶538±152)均明显短于催产素组;普贝生组剖宫产率明显低于催产素组(13.3%∶31.2%),自然分娩率明显高于催产素组(86%∶55%);宫缩乏力的发生率明显低于催产素组(22.2%∶6.6%);普贝生组在高张宫缩、过频宫缩、新生儿窒息率、胎儿窘迫发生率方面与催产素组无显著差异。结论与小剂量催产素引产相比较,普贝生具有良好的促宫颈成熟作用,在足月引产的使用中是安全有效的。

Objective： evaluate security and effectiveness of prostaglandin E2. Methods ： our research totally selected 114 pregnancies, and 54 pregnancies as control group were recommended oxytocin induction, and 60 pregnacies as case group prostaglandin E2 induction, then take case control study to evaluate security and effectiveness of prostaglandin E2 induction. Compared cervical maturity （ cervical Bishop scoring） and time to and the time of first / second stage labor of case group to control group to evaluate effectiveness of prostaglandin E2 induction; compared incidence rate of overpowerful and overfrequent uterine contraction and fetal distress cesarean section to evaluate security of prostaglandin E2 induction, all data were dealt with SPSS 10. 0 statistic software. Results： cervical Bishop grade of case group is significantly higher than control group （94. 2% ： 11.1% ）, the incidence rate of case group at the respect of has not obviously statistic significance. Conclusion： Prostaglandin E2 induction compared with oxytocin induction has better effect, and prostaglandin E2 used in trimester pregnancy induction has affirmatively security and effectiveness.