达英-35、补佳乐、克罗米芬序贯用药治疗多囊卵巢综合征不孕50例

Diane- 35, progynova, clomiphene sequential drug for the treatment of polycystic ovary syndrome in 50 cases

目的观察达英-35、补佳乐、克罗米芬序贯用药治疗多囊卵巢综合征（PCOS）的疗效。方法选择PCOS患者100例，随机分成治疗组（A组）、观察组（B组）各50例，A组用达英-35治疗3个周期后序贯应用补佳乐、克罗米芬、绒毛膜促性腺激素治疗，B组应用克罗米芬、绒毛膜促性腺激素治疗。观察临床指标：月经情况、痤疮、多毛改善情况。生化指标：血清生殖激素水平：黄体素（LH）、卵泡刺激素（FSH）、睾酮（T）、雌二醇（E2）。超声指标：排卵率、妊娠率、流产率。结果患者月经趋于规律，面部痤疮明显减少，毛发生长减少、变细。血清LH值、T值明显下降，LH／FSH值正常。排卵率、妊娠率明显提高，流产率降低。结论达英-35、补佳乐、克罗米芬序贯用药治疗PCOS不孕症临床症状明显改善，生殖激素水平趋于正常。排卵率、妊娠率得以提高，流产率及LUFS发生率下降。

Objective To investigate the treatment of polycystic ovary syndrome （PCOS） with Diane - 35,progynova drug and clomiphene sequential. Methods One hundred patients with PCOS,half for the treatment,half for the oberservement. Use Diane - 35 to the treatment group （group A） for three months,then the cycle sequential treatment of progynova, clomiphene, and the treatment of cashmere promoting. Observation group（group B） used the clomiphene and the treatment of cashmere promoting. Observe the clinical symptoms that whether improved, serum levels of reproductive hormones, ovulation rate, the pregnancy rate and abortion rate and the incidence of LUFS had significant differences. Results Patients tend to menstrual regularity, significantly reduce facial ache,hair growth reduced, thinned. Serum LH values,T values significantly decreased and LH / FSH values became normal. Ovulation rate,the pregnancy rate markedly improved, the abortion rate decreased. Conclusion Diane - 35, with progynova, clomiphene sequential treatment of infertility treatment PCOS symptoms markedly improved, and reproductive hormone levels close to be normal. Ovulation rate, the pregnancy rate will increase and the abortion rate and the incidence of LUFS will decline.