坦索罗辛治疗输尿管下段结石140例

The Clinical Results of Tamsulosin in Treatment of Lithiasis in Lower Ureters

目的探讨α1受体阻断药坦索罗辛对输尿管下段结石的疗效。方法输尿管下段结石患者278例,分为两组,对照组138例,常规治疗:口服排石颗粒5.0g,tid,4周,同时每日饮水>2000mL;治疗组140例,常规治疗+口服坦索罗辛0.4mg,qd,4周。结果对照组结石排出率52.17%,平均排出时间(10±7)d,治疗期间肾绞痛平均发作2.0次;治疗组结石排出率84.29%,平均排出时间(7±3)d,治疗期间肾绞痛平均发作1.0次;两组排出率比较差异有显著性(P<0.05)。结论坦索罗辛治疗输尿管下段结石能明显提高结石排出率,缩短排出时间,减少治疗期间肾绞痛的发作次数。

Objective To assess the effect of tamsuiosin （alpha 1 receptors blocker） in treatment of ureterolithiasis localized in the lower ureters. Methods From July 2004 to December 2006,278 patients with ureterolithiasis in the lower ureters were randomly divided into two groups： group A （n =138） was subjected to our regular treatment（0.5 g PSKL rid）and group B （ n = 140） was regular treatment combined with tamsulosin 0.4 mg qd. Results In group A, 52.17% of the patients expelled the calculi and was lower than 84.29% in group B. The mean time discharged calculis in group A was more longer and incidence of renal colics more frequent, compared with group B [ （ 10 ±7） days vs （7 ± 3） days, 2.0 times vs 1.0 times,respectively） ]. Conclusion The treatment by tamsulos might accelerate calculi discharge from the lower ureters and be safety.