摘要
目的采用糖尿病大鼠模型，观察氟伐他汀对大鼠肾脏保护作用的机制。方法以链脲佐菌素（STZ）制备糖尿病大鼠模型，将SD大鼠随机分为正常对照组、糖尿病组、小剂量氟伐他汀治疗组2mg／（kg·d）和大剂量氟伐他汀治疗组4mg／（kg·d）。4周后检测各组大鼠血胆固醇、甘油三酯、血肌酐和24h尿蛋白，用RT-PCR检测肾组织转化生长因子（TGF-β1）的表达。结果糖尿病大鼠肾组织TGF-β1表达较正常肾组织增高，治疗4周后，氟伐他汀对血脂水平、蛋白尿无影响，但可明显降低糖尿病肾病大鼠肾小管间质中TGF-β1的表达，且随剂量增多TGF-β1下降更明显。结论氟伐他汀对糖尿病大鼠肾脏保护作用可能通过非依赖降脂的保护作用，其机制至少部分与下调肾小管间质中TGF-β1表达有关。
Objective To study the protective effects of fluvastatin on the renal lesions in diabetic rat. Methods The model of diabetic rats was induced by streptozotocin. SD rats were random divided into four groups ： Control group, diabetic rats group, low-dose fluvastatin group 2mg/（ kg· d） and high-dose fluvastatin group 4 mg/（ kg·d）. After treatment for 4 weeks, serum cholesterol, serum creatinine and urinary protein were measured respectively. The expression of TGF 131 in the renal cortex was determined by RT-PCR. Results Fluvas- tatin inhibited the expression of TGF-β1 mRNA in a dose-dependent manner, and had no influence on urinary protein, serum cholesterol and serum creatinine. Conclusions Fluvastatin inhibits the overexpression of TGF -β1 mRNA, which may be related to independent cholesterol decreasing effect.
出处
《中国医师杂志》
CAS
2008年第5期587-589,共3页
Journal of Chinese Physician
