冠心病患者中脂联素在冠状动脉损害中的意义

The significance of adiponectin in coronary damage of patient with coronary heart disease

目的探讨冠心病患者血浆脂联素水平与冠状动脉粥样硬化病变的关系。方法根据选择性冠状动脉造影结果将142例患者分为冠心病组和对照组。冠心病组根据临床诊断分为稳定型心绞痛（SAP）组和急性冠脉综合征（ACS）组；根据冠状动脉病变类型分为A型病变、B型病变和C型病变组；根据冠状动脉病变程度分为轻度病变、中度病变和重度病变组。血浆脂联素浓度通过ELISA方法测定。结果冠心病组脂联素浓度明显低于对照组（（6．09±1．85）μg／ml vs （10．25±1．51）μg/ml，P〈0．001），ACS组脂联素浓度又明显低于SAP组（5．45±1．53）μg／ml vs（7．60±1．67）μg／ml，P〈0．001）。随冠状动脉病变类型和病变程度的加重，脂联素浓度逐渐降低，各组间差异有统计学意义（P〈0．001）。结论脂联素是冠状动脉粥样硬化的负调控因子，低脂联素血症可以做为预测冠状动脉粥样硬化病变情况及斑块稳定性的一个指标。

Objective To investigate the relationship between the plasma adiponectin concentration and coronary arteriosclerosi： change in patient with coronary heart disease （CHD）. Method 142 patients were divided into CHD group and control group according to the Coronary Angiography （CAG）, CHD group were further divided into stable angina pectoris （SAP） subgroup and acute coronary syndrome （ACS） subgroup according to the clinical property, According to the type of coronary change, CHD group was divided into A type group, type group and C type group, meanwhile according to the degree of coronary lesion, CHD group was divided into light stenosis group, model ate stenosis group and severe stenosis group. The plasma adiponectin concentration was measured by ELISA. Results The plasma adiponec tin concentration in CHD group was＇significant lower than that in control group. The plasma adiponectin concentration in ACS subgroup wa significant lower than that in SAP subgroup. The plasma adiponectin concentration decreased gradually from A type group to C type group and from light stenosis group to severe stenosis group （ P 〈 0. 001 ）. Conclusions Adiponectin is a negative regulatory factor of coronary ather osclerosis, and Hypoadiponectin may be used to predict the change of coronary arteriosclerosis and the stability of plaque.