摘要
目的观察腺苷蛋氨酸治疗病毒性肝炎高胆红素血症的临床疗效.方法选择总胆红素>171μmol/L的病毒性肝炎214例,随机分为治疗组108例和对照组106例,两组均给予内科基本治疗,治疗组加用腺苷蛋氨酸1 000 mg,静滴,Qd,比较两组疗效的差异.结果治疗组皮肤骚痒、乏力、纳差的改善率明显优于对照组(P<0.05),急黄肝及重度慢性肝炎治疗组血清总胆红素的下降程度明显大于对照组;肝功能复常率及总有效率均高于对照组,且复常时间明显快于对照组(P<0.05),亚重肝及慢重肝,治疗组及对照组总疗效有统计学意义,未观察到腺苷蛋氨酸相关的任何不良反应发生.结论腺苷蛋氨酸治疗急黄肝及重度慢性肝炎高胆红素血症,疗效确切,用于治疗亚重肝及慢重肝可缓解患者的皮肤瘙痒、乏力、纳差等临床症状.
Objective To observe the therapeutic effect of Ademetionine in treating hyperbilirubinemia-virus hepatitis. Metbods 214 cases of hyperbilirubinemia -virus hepatitis patients （whose serum total bilirubin （STB） more than 171 μmoL / L） were randomly divided into treatment group （n = 108） and control group （n = 106）. The same basic therapy was applied to the two groups. Ademetionine was given to the treatment group with a dosage of 1 000 mg intravenous drip once a day for 4 weeks. The therapeutic effect on patients in the two groups were compared. Results The efficiency for the dermato pruritus, fatigue or anorexia in treatment group was better than control group （P 〈 0.05）. For Acute icteric hepatitis （AIH） and Severe chronic hepatitis （SCH） patients, the efficiency for liver function returning to normal and the total efficiency in treatment group were higher than control group （P 〈 0.05）. The time for the liver function returning to normal for AIH and SCH in the treatment group were shorter than that of the control group （P 〈 0.05）. For AIH and SCH patients, The degree of STB declined in the treatment group were more than that of the control group （P 〈 0.05）. For Subacute hepatitis gravis （SHG） and chronic hepatitis gravis （CHG） patients, there was no difference between treatment group and control group. No side effect related to Ademetionine was found. Conclusions Ademetionine is an effective assistant drug for the treatment of AIH and SCH. It can also be used to alleviate clinical symptoms （the dermatopruritus, fatigue and anorexia） of patients with SHG and CHG.
出处
《昆明医学院学报》
2008年第2期104-108,共5页
Journal of Kunming Medical College
