埃索美拉唑治疗反流性食管炎的疗效评价

The Valuation of Curative Effect on Backstreaming Esophagitis Treated by Esomeprazole

目的比较埃索美拉唑与奥美拉唑治疗反流性食管炎(RE)的疗效.方法256例青年RE患者随机分为2组,治疗组口服埃索美拉唑20 mg,1次/d;对照组口服奥美拉唑20 mg,1次/d;疗程均为8周,均合用莫沙必利5 mg,3次/d.治疗4周、8周时分别作症状评价和胃镜评价.结果治疗后两组症状及胃镜下疗效观察均有明显改善,治疗组疗效高于对照组(P<0.05).结论埃索美拉唑治疗青年RE有效、安全,疗效优于奥美拉唑.

Objective To evaluate curative effect by comparing Esomeprazole with Omeprazole to treat backstreaming esophagitis. Method 256 young patients with backstreaming esophagitis were divoded into two groups, The patients of treated group were oral administration with Esomeprazole 20 mg qd, The patients of control group were oral administration with Omeprazole 20 mg qd, two groups lasted 8 weeks, meanwhile gave Mosapride 5 mg Tid by oral administration. Two groups were given symptom valuation and gastroscope valuation when on fourth week and eighth week. Results After treated, two groups＇ symptom and curative effect by gastroscope observation were improved, but curative effect of treated group was significantly better than control group＇s （P 〈 0.05）. Conclusion Esomeprazole is effective and safe to treat young patients with backstreaming esophagitis, its curative effection outstrips Omeprazole.