食管鳞癌淋巴管生成因子表达与淋巴结转移的关系

Relationship between expression of VEGF-C and lymph node metastasis in human esophageal squamous carcinoma

目的:探讨淋巴管生成因子(VEGF-C)的表达与食管鳞癌淋巴结转移的关系。方法:采用免疫组化法检测49例食管鳞癌组织及其周围正常食管组织中VEGF-C的表达,并结合食管鳞癌的淋巴结转移特征进行分析。结果:VEGF-C在食管鳞癌组织和对应正常组织中阳性表达率分别为71.4%和12.2%。有淋巴结转移组(N1)VEGF-C蛋白阳性表达率73.3%,明显高于无淋巴结转移组(N0)32.6%(P<0.05)。结论:食管鳞癌组织中存在VEGF-C的高表达,可能与食管癌的淋巴结转移有关。VEGF-C蛋白表达可能作为推断食管鳞癌淋巴结转移的参考指标。

Objective：To explore the expression of VEGF - C in human esophageal squamous carcinoma and its relationship with lymph node metastasis. Methods ：The expression of VEGF -C in 49 specimens of esophageal squa-mous carcinoma and normal tissues were detected by immunohistochemistry. Results： The positive rates of VEGF - C were 71.4% （35/49） and 12.2% （6/49） in esophageal squamous carcinoma and normal tissue（ P 〈 0.05 ） respectively. The expression of VEGF - C was significantly higher in cases with lymph node metastasis 73.3% （22/30） than in those without lymph node metastasis 32.6% （ 6/19 ）, （ P 〈 0.05 ）. Conclusion ： There is an overexpression of VEGF - C in esophageal squamous carcinoma tissues. Which may correlate with lymph node metastasis. The expression of VEGF - C might be used as a useful marker of lymph node metastasis in esophageal squamous carcinoma.