摘要
目的:研究吉西他滨(GEM)联合顺铂(DDP)对晚期肺腺癌的客观疗效和毒副反应。方法:GEM1000mg/m2静脉注射,第1、8天,DDP25mg/m2静脉滴注,第1-3天,21天为1周期。按WHO标准评价疗效及毒副反应。结果:50例均可评价疗效,其中完全缓解(CR)1例,部分缓解(PR)23例,有效率(RR)48%,中位生存期9.3月。1年生存率34.0%。毒副反应为骨髓抑制、恶心、呕吐等。结论:GP方案治疗晚期肺腺癌初治患者疗效较高,毒副反应可耐受。
Objective：To analyse the effect and toxicity of gemcitabines（GEM） plus cisplatin in the treatment of patients with advanced adenocarcinoma lung cancer. Methods： Gemcitabine 1000mg/m^2 was infused dl, d8, cisplatin 2.5mg/m^2 was infused dl - d3. The regimen was repeated every 21d. Results：For 50 cases ,there were 1 CR ,23 PR,and RR were 48% ; the median survival duration was 9.3 months;1 - year survival rate was 34.0%. The maior toxicity was bone marrow deprssion and gastrointestinal effects. Conclusion： GEM plus DDP combination chemotherapy is an effective regimen in initial treatment advanced adenocarcinoma lung cancer and toxicity is acceptable.
出处
《现代肿瘤医学》
CAS
2008年第6期984-985,共2页
Journal of Modern Oncology
关键词
肺腺癌
吉西他滨
顺铂
化疗
adenocarcinoma lung cancer
gemcitabine
cisplatin
chemotherapy
