DMBT1、E-cadherin在食管鳞癌中的表达及其生物学意义

Expression and biological significance of DMBT1,E-cadherin in esophageal squamous carcinoma

目的:探讨食管鳞癌组织中抑癌基因DMBT1以及粘附分子E-cadherin的表达及其与肿瘤生物学行为的关系。方法:应用免疫组织化学方法检测70例食管鳞癌组织,23例切缘正常组织中DMBT1、E-cad-herin的表达情况。结果:DMBT1、E-cadherin在癌组织中的表达减弱或呈阴性。DMBT1、E-cadherin的表达与食管鳞癌组织的分化程度、淋巴结的转移有关(P<0.05),与癌组织的浸润深度无关(P>0.05)。结论:DMBT1、E-cadherin的表达减弱是食管鳞癌组织低分化和高度恶性的生物学标志,并与淋巴结的转移密切相关。

Objective：To investigate the expression of DMBT1, E - cadherin in esophageal squamous carcinoma and the relationship to biological behavior of tumors. Methods：The expression of DMBT1 and E - cadherin was examined by immunohistochemistry （IHC） in 70 cases of esophageal squamous carcinoma and 23 cases of incisal margin normal tissues. Results ：The expression of DMBT1 and E- cadherin in esophageal squamous carcinoma was weak or negative. The expression of DMBT1 and E - cadherin was related with histological differentiation degree, lymph node metastasis （P 〈 0.05）. Conclusion ： Weak or negative expression of DMBT1 and E - cadherin could be a biological markers of poor differention , high malignancy and lymph node metastasis of esophageal squamous carcinoma.