合肥市某计免门诊儿童麻疹疫苗免疫后抗体水平分析

Investigation of Measles Antibody Level of Children Vaccinated by Measles Vaccine in a EPI vaccination clinic in Hefei

目的了解麻疹疫苗初免1针后抗体阳转率水平与麻疹疫苗初免和加强接种2针后的抗体阳转率水平,评价麻疹疫苗的接种质量和复种效果。方法采用ELISA方法检测血清麻疹IgG抗体,把某计免门诊343名儿童抗体水平监测资料和合肥市3818名儿童抗体水平监测资料进行比较。结果该计免门诊儿童以及合肥市总体儿童在接种2针麻疹疫苗后抗体阳转率均高于接种1针麻疹疫苗后的抗体阳转率,(2χ分别为8.86和14.59,P均小于0.01)差异均有显著性意义。结论麻疹疫苗复种能明显提高抗体阳转率。

Objective To understand measles antibody sero-positive rates of children with initial vaccination and the second vaccination and evaluate measles vaccination quality and effect of revaccination. Methods ELISA method was used to detect measles serum IgG antibody. Antibody level of 343 children vaccinated in the vaccination clinic was compared with that of 3,818 children in Hefei city. Results Antibody sero-conversion rate level after the second vaccination was higher than that of the initial vaccination both in the clinic and in Hefei. The differences were statistically significant （X^2 respectively 8.86 and 14.59. P 〈 0.01.）. Conclusion Revaccination of measles vaccine could significantly improve the sere-positive rate.