32例胸腺瘤合并重症肌无力的外科治疗分析

Surgical treatment for 32 cases of thymoma with myasthenia gravis

目的总结、探讨胸腺瘤合并重症肌无力（MG）诊断及治疗经验。方法回顾分析1993年6月~2007年6月接受手术治疗的32例胸腺瘤合并MG的临床资料。分析其临床特点、手术径路及围手术期处理等。结果术后28.1%的患者发生MG危象,在院死亡率为6.2%。MG临床分型与胸腺瘤病理类型的关系差异无统计学意义。结论胸部CT检查有助于早期发现胸腺瘤。完善围手术期管理,减少MG危象发生,手术治疗MG合并胸腺瘤可获良好疗效。

Objective To investigate and to summarize the experiences in the diagnosis and surgical treament of myasthenia gravis associated with thymoma. Methods The data of 32 eases of thymoma associated with myasthenia gravis which underwent surgical treatment from June, 1993 to June, 2007 were analyzed retrospectively. Clinical characteristics, operative approach and perioperative manage- ments was analyzed. Results MG crises were seen in 28. 1% of patients postoperatively, the mortality of in - patients ＇after operation was 6.2%. There were no statistically difference in clinical type of MG and pathological type of thymoma. Conclusions Chest CT can increase the accuracy early diagnosis of thymoma. Satisfactory therapeutic effect can be achieved with surgical treatment for thymoma associated with myasthenia gravis. Perioperative management is very important to avoid crisis of myasthenia gravis.