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FHL家族与肿瘤的关系 被引量：2

FHL Family and Tumor
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摘要 FHL(four and half LIM domains)是LIM-only蛋白家族的重要成员。FHL家族包括FHL1～FHL5共5个成员,它们具有组织特异性。研究发现,FHL参与转录调节、信号转导、凋亡等,是细胞生长、分化的重要调节因子。已证实FHL1、FHL2与不同组织来源肿瘤的发生和发展有关。FHL表达水平是某些肿瘤预后的相关因素。研究FHL与肿瘤的关系,有利于阐明肿瘤的病理生理机制。 The Four and Half LIM domains（FHL） are composed of the five members FHL1-FHLS, and belong to the LIM-only protein subclass. They are expressed in a cell-and tissue-specific manner. It has been proved that FHL is a important regulatory factor in cell growth and differentitation by participating in transcriptional regulation, signal transduction, apoptosis and so on. Up to now, FHL1 and FHL2 of FHL family are proved to be involved in development and progression of tumors from several tissues. Expression level of FHL correlated with prognosis in some tumors. Investigating the relationship between FHL and tumor is helpful for elucidating tumor biology.
作者 郭俊唐 周乃康 叶棋浓
机构地区 解放军总医院胸外科 军事医学科学院生物工程研究所
出处 《生物技术通讯》 CAS 2008年第3期443-444,共2页 Letters in Biotechnology
关键词 Four and HALF LIM domains(FHL) Lin-Isl-Mec(LIM) 肿瘤 Four and half LIM domains（FHL） Lin-Isl-Mec（LIM） Tumor
分类号 Q51 [生物学—生物化学] Q75 [生物学—分子生物学]
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参考文献23

  • 1Lee S M, Tsui S K, Chan K K, et al. Chromosomal mapping, tissue distribution and cDNA sequence of four-and-a-half LIM domain protein 1 (FHL1)[J]. Gene, 1998,216(1):163-170.
  • 2Lee S M, Li H Y, Ng E K, et al. Characterization of a brain-specific nuclear LIM domain protein(FHL1B) which is an alternatively spliced variant of FHLI[J]. Gene, 1999,237(1):253-263.
  • 3Ng E K, Lee S M, Li H Y, et al. Characterization of tissue-specific LIM domain protein(FHL1C) which is an alternatively spliced isoform of a human LIM-only protein(FHL1)[J]. J Cell Biochem, 2001,82(1):1-10.
  • 4Chan K K, Tsui S K, Lee S M, et al. Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart[J]. C, ene, 1998,210(2):345-350.
  • 5Lee S M, Tsui S K, Chan K K, et al. Chromosomal mapping of a skeletal muscle specific LIM-only protein FHL3 to the distal end of the short arm of human chromosome l[J]. Somat Cell Mol Genet, 1998,24(3):197-202.
  • 6Morgan M J, Madgwick A J. The fourth member of the FHL family of LIM proteins is expressed exclusively in the testis[J]. Biochem Biophys Res Commun, 1999,255(2):251-255.
  • 7Mistry A C, Kato A, Tran Y H, et al. ACT, a novel actin-binding protein, is highly expressed in eel gill pillar cells and responds to wall tension [J]. Am J Physiol Regul Integr Comp Physiol, 2004,287(5):1141-1154.
  • 8Shen Y Q, Jia Z Y, Nagele R G, et al. Sac uses Cas to suppress Fhll in order to promote nonanchored growth and migration of tumor cells[J]. Cancer Res, 2006,66(3)1543-1552.
  • 9Banner A E, Lemon W J, Devereux T R, et al. Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocascinomas[J]. Oneogene, 2004,23(5):1166-1176.
  • 10Morgan M J, Whawell S A, The structure of the human LIM protein ACT gene and its expression in tumor cell lines[J]. Biochem Biophys Res Commun, 2000,273(2):776-783.

同被引文献20

  • 1李翠玲.转化生长因子β分子生物学研究进展[J].国外医学（免疫学分册）,1995,18(3):124-127. 被引量：15
  • 2曹禹,李智,封瑞.肺动脉高压大鼠肺动脉平滑肌上calponin和TGFβ1的变化[J].中国药理学通报,2007,23(2):277-278. 被引量：8
  • 3Ding L, Wang Z, Yan J, et al. Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-β-like signaling pathway [J]. J Clin Invest, 2009, 119(2): 349-361.
  • 4Kleiber K, Strebhardt K, Martin BT. The biological relevance of FHL2 in tumour cells and its role as a putative cancer target [ J]. Anticancer Res, 2007, 27(1A) : 55-61.
  • 5Wang J, Yang Y, Xia HH, et al. Suppression of FHL2 expression induces cell differentiation and inhibits gastric and colon carcinogenesis [ J ]. Gastroenterology, 2007, 132 ( 3 ) : 1066-1076.
  • 6Shen YQ, Jia ZY, Nagele RG, et al. Sac uses Cas to suppress Fhl1 in order to promote nonanchored growth and migration of tumor cells [ J]. Cancer Res, 2006, 66(3) : 1543-1552.
  • 7Paul C, Lacroix M, Iankova I, et al. The LIM-only protein FHL2 is a negative regulator of E4F1 [ J ]. Oncogene, 2006, 25 ( 40 ) : 5475 -5484.
  • 8Bonner AE, Lemon WJ, Devereux TR, et al. Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas [ J]. Oncogene, 2004, 23 (5) : 1166-1176.
  • 9Sakashita K, Mimori K, Tanaka F, et al. Clinical significance of loss of Fhll expression in human gastric cancer [ J ]. Ann Surg Oncol, 2008, 15(8) : 2293-2300.
  • 10Seholl FA, McLoughlin P, Ehler E, et al. DRAL is a p53- responsive gene whose four and a half LIM domain protein product induces apoptosis [J]. J Cell Biol, 2000, 151(3): 495- 506.

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生物技术通讯
2008年 第3期

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