中西医结合治疗急性冠脉综合征临床疗效观察

Clinical observation on therapeutic effects of combination of traditional Chinese and western medicine for treatment for acute coronary syndrome

目的观察中西医结合治疗急性冠脉综合征(ACS)的临床疗效。方法将60例ACS患者随机分为两组。治疗组在抗血小板、抗凝、降脂、扩张冠状动脉、降压、保护血管内皮功能等常规治疗基础上服用中药复方苏欣康颗粒;对照组在常规治疗基础上加用复方丹参滴丸。2周为1个疗程,1个疗程结束后观察治疗前后临床症状、心电图、24h动态心电图变化,并判定疗效。结果经2周治疗后,治疗组总有效率(90.0%,27/30)显著高于对照组(83.3%,25/30),差异有统计学意义(P<0.05)。治疗组临床症状的改善程度高于对照组,其中以对心悸、自汗及心肾阳虚的改善最显著(P均<0.05)。治疗组心律失常发生率(36.7%)低于对照组(50.0%),但差异无统计学意义(P>0.05)。结论中药复方苏欣康结合常规手段治疗ACS疗效确切,可作为治疗ACS的有效方剂。

Objective To observe the clinical therapeutic effect of combination of traditional Chinese medicine （TCM） and western medicine for treatment for acute coronary syndrome （AC5）. Methods Sixty patients with ACS were randomly divided into 2 groups： the treatment group and the control group. The combined treatment group was treated with conventional therapy （anti-platelet, anticoagulation, therapies for lowering blood-lipids and blood pressure, dilatation of coronary artery and protection of vascular endothelial function） and TCM complex prescription named Suxinkang granules （复方苏欣康颗粒）, the control group was treated with conventional therapy and drop pills of salvia miltiorrhiza （复方丹参滴丸）. Two weeks of treatment constituted one therapeutic course, and after one therapeutic course, the clinical symptoms, manifestations of electrocardiogram （ECG） and dynamic ECG changes in 24 hours were recorded. Results The total effective rate of combined treatment group was significantly higher than that of the control group （90.0%（27/30） vs. 83.3%（25/30）, P〈0.051 after 2 weeks of treatment. The improvement of clinical symptoms （especially in heart palpitation, perspire spontaneously, deficiency of the heart yang and kidney yang） of combined treatment group was significantly better than that in the control group （all P 0.05） and the incidence of arrhythmia in the treatment group was lower than that in the control group （36.7% vs. 50. 0%, P〉0. 05）. Conclusion The TCM complex prescription Suxinkang has a certain curative effect on ACS and it is an effective method in combination of traditional Chinese and western medicine for treatment of ACS.