摘要
目的:探讨病毒性脑炎患儿血浆D-二聚体含量与病情及预后的相关性。方法:选择2003年1月～2006年12月我院90例不同病情的病毒性脑炎患儿作为观察组,对照组选择同期我院儿童保健科健康体检儿童30例,D-二聚体采用免疫比浊法定量测定。结果:急性期观察组血浆D-二聚体含量明显高于对照组,二者之间有显著性差异(P<0.01);D-二聚体含量在轻症组与重症组之间有显著性差异(P<0.01),病情越重D-D升高越明显,D-D升高与病情呈正相关(P<0.01)。预后不良组血浆D-二聚体含量明显高于预后良好组,二者之间有显著性差异(P<0.01);恢复期观察组血浆D-二聚体含量明显下降,接近对照组水平,与对照组比较无显著性差异(P>0.05)。结论:血浆D-二聚体含量的定量测定有助于早期、准确地判断病毒性脑炎患儿病情严重程度及预后。
Objective： To study the correlation between the levels of D - dimer （ D - D） and the severity and prognosis of viral en- cephalitis. Methods： The concentration of D - D in plasma were measured by immunoturbidimetry. Results. In the acute phase, the levels of D - D in children with viral encephalitis increased markedly compared with that in healthy control group, the concentration of D - D correlated positively with the severity of viral encephalitis; in the convalescent phase, the levels of D - D were restored progressively when viral encephalitis turned for the better, there was no significant difference between the children with viral encephalitis in the convalescent phase and the control group （ P 〉 0. 05 ） ; There was a negative correlation between the levels of D - D and the prognosis （ P 〈 0. 01 ）.Conclusion ： The measurement of D - D in plasma may be useful to judge the severity and prognosis of viral encephalitis in early stage.
出处
《中国妇幼保健》
CAS
北大核心
2008年第16期2291-2293,共3页
Maternal and Child Health Care of China
基金
深圳市宝安区科技局科研基金资助项目(项目编号:2005170)
