慢性重症肝炎和肝硬化患者医院感染调查分析

Analysis on hospital infection of chronic hepatitis gravis and hepatic cirrhosis

目的:探讨慢性重症肝炎及肝硬化患者发生医院感染情况,为防治医院感染提供依据。方法:回顾性调查2007年度收住本院的慢性重症肝炎及肝硬化患者发生医院感染的情况。结果:医院感染率为13.7%,恶化或死亡的医院感染率(18.5%)高于好转或痊愈组(12.4%)(P<0.05)。患者年龄越大,并发医院感染越多(P<0.001)。院内感染以腹腔感染占首位,致病菌以真菌或条件致病菌为主;其易感因素为免疫抑制剂和广谱抗生素的使用、侵入性诊疗、糖尿病等;医院感染导致各种严重致死性的并发症增多(42/113)。结论:慢性重症肝炎及肝硬化患者易发生医院感染,院内感染会使病情恶化或死亡发生率增高,预后差。

Objective：To investigate the hospital infection of chronic hepatitis gravis and hepatic cirrhosis, and to provid possible ways to prevent and cure the infection. Methods：Patients with chronic hepatitis gravis and hepatic cirrhosis, treated in 2007, were retrospectively reviewed. Results：The rate of hospital infection was 13.7%. The rate of aggravation group（ 18.5% ） was higher than that in restoration group （ 12.4% ） （ P 〈 0.05 ）. Patients who were older had more hospital infection （ P 〈 0.001 ）. peritonitis was the first place in the hospital infection, and the main pathogenic was eumycete or conditional pathogenic bacteria. To use immune depressant and broad - spectrum antibiotic, treatment of virulence and diabetes showed positively correlated with hospital infection. The infection was caused much more fatal complication （42/113）. Conclusion： Patients with chronic hepatitis gravis and hepatic cirrhosis was easy to have hospital infection and this induced patients condition worse or death.