空气流量控制在阿维菌素发酵过程中的应用

Application of aeration control in the avermectin fermentation

在S.avermitilis发酵过程中引入质谱仪进行尾气的在线测定.发现正常过程产素期临界通气量为1600m3/h;前期的OUR数值可以用于预测发酵正常与否;在非正常批次,产素期在尾气数据指导下利用空气流量限制发酵的初级代谢水平,起到部分恢复产素速率的效果.

Method of using mass spectrometer to the exhaust gas on-line analysis was successfully applied into fermentation processes of avermectin in China for the first time. The critical inlet air flux was found to be 1 600 m3/h, and OUR value in prophase could be used to indicate future trend of the batch. For an abnormal batch, with the restriction of primary metabolism under guidance of the exhaust gas data, yielding rate of avermectin was restored to a normal level.