摘要
目的探讨山茱萸提取物的补肾阳作用。方法应用外源性糖皮质激素所致的肾阳虚动物模型,观察山茱萸提取物对肾阳虚大鼠下丘脑促肾上腺皮质激素释放激素(CRH)分泌及钙调蛋白(CaM)mRNA表达的影响。结果山茱萸提取物使肾阳虚大鼠下丘脑CaM mRNA的表达量减少,CRH分泌增多。结论山茱萸提取物具有较显著的补益肾阳功效。
Objective To explore effects of extra of Fructus Corni （FCE） on tonifying kidney-yang. Methods The animal model of kidney-yang deficiency with the hydrocortisone was made by exogenous glucocorticoid. Effects of the extract of Fructus Corni on the kidney-yang deficiency rats was observed. Results The FCE can decrease the levels of calmodulin（ CaM ） mRNA and increase the secretion of CRH in the hypothalamus. Conclusion The extract of Fructus Corni have significant protecting efficacy in the animal＇s model with kidney-yang deficiency.
出处
《滨州医学院学报》
2008年第3期179-181,共3页
Journal of Binzhou Medical University
关键词
山茱萸提取物
肾阳虚
钙调蛋白
下丘脑
促肾上腺皮质激素释放激素
extract of Fructus Corni （ FCE ） ,kidney-yang deficiency,calmodulin （ CaM ） ,hypothalamus,corticotrophin releasing factor（ CRH ）
