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Sugammadex(Org25969)研究进展

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出处 《安徽医药》 CAS 2008年第6期481-482,共2页 Anhui Medical and Pharmaceutical Journal
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参考文献12

  • 1Epemolu O, Mayer I, Hope F, et al. Liquid chromatography/mass spectrometric bioanalysis of a modified γ-cyclodextrin ( Org 25969) and rocuronium bromide (Org9426) in guinea pig plasma and uline :its application to determine the plasma pharmacokinetics of Org 25969 [ J ]. Rapid Commun Mass Spectrom, 2002, 16 ( 20 ) :1946 -52.
  • 2Boer HD, Egmond J, Pol DF, et al. Sugammadex, a new reversal agent for neuromuscular block induced by roeuronium in the anaesthetized Rhesus monkey [ J ]. Br J Anaesth,2006,96 (4) :473 - 9.
  • 3Epemolu O, Bom A, Hope F, et al. Reversal of neuromuscular blockade and simultaneous increase in plasma rocuronium concentration after the intravenous infusion of the novel reversal agent Org 25969 [ J ]. Anesthesiology,2003,99 (3) :632 - 7.
  • 4Gijsenbergh F, Ramael S, Houwing N, et al. First human exposure of Org 25969, a novel agent to reverse the action of rocuronium bromide [ J ]. Anesthesiology,2005,103 (4) :695 - 703.
  • 5Sorgenfrei IF, Norrild K, Larsen PB, et al. Reversal of rocuronium - induced neuromuscular block by the selective relaxant binding agent Sugammadex:a dose -finding and safety study[ J]. Anesthesiology,2006,104(4) :667 -74.
  • 6Groudine SB, Soto R, Lien C, et al, A randomized, dose-finding, phase Ⅱ study of the selective relaxant binding drug, Sugammadex, capable of safely reversing profound rocuronium-induced neuromuscular block [ J ], Anesth Analg,2007,104 ( 3 ) :555 - 62.
  • 7Suy K, Morias K, Cammu G, et al. Effective reversal of moderate rocuronium-or vecuronium-induced neuromuscular block with Sugammadex ,a selective relaxant binding agent [ J ]. Anesthesiology, 2007,106(2) :283-8.
  • 8Vanacker BF, Vermeyen KM, Struys MM, et al. Reversal of rocuronium-induced neuromuscular block with the novel drug Sugammadex is equally effective under maintenance anesthesia with propofol or sevoflurane [ J ]. Anesth Analg,2007,104 ( 3 ) :563 - 8.
  • 9Lenz A, Hill G, White PE. Emergency use of Sugammadex after failure of standard reversal drugs [ J ]. Anesth Analg, 2007,104 ( 3 ) :585 -6.
  • 10Kopman AF, Mallhi MU, Neuman GG, et al. Reestablishment of paralysis using mivacurium following apparent full recovery from miracurium-induced neuromuscular block [ J ]. Anaesthesia, 1996,51:41-4.

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