精神分裂症伴发代谢综合征者的相关危险因素及生活质量研究

Investigation of the relative factors and quality of life of metabolic syndrome in schizophrenics

目的:研究国内精神分裂症伴发代谢综合征者的患病率及生活质量,并分析可能的相关影响因素。方法:对602例住院精神分裂症患者进行问卷调查(包括国内修订的生活质量综合评定问卷等)和实验室测定空腹血糖及甘油三酯等,代谢综合征的诊断标准采用2004年中华医学会糖尿病分会代谢综合征标准。结果:精神分裂症患者中代谢综合征患病率为35.5%。与代谢综合征患病风险相关的危险因素包括年龄、性别、抗精神病药物种类及病程(P(0.05)。生活质量方面,精神分裂症伴发代谢综合征患者的躯体功能、心理功能和社会功能3个维度及总分显著低于非代谢综合征者(P<0.01)。精神分裂症患者的血糖、血压及BM I异常明显降低精神分裂症患者生活质量。结论:精神分裂症患者具有较高的代谢综合征发病风险,可能危险因素包括女性、高龄、病程长及服用氯氮平药物等。精神分裂症伴发代谢综合征者具有较差的躯体、心理及社会功能,可能与不良躯体状况有关。

Objective：To evaluate the prevalence and quality of life of metabolic syndrome in schizophrenics and explore the relative factors, nethods：Patient＇s data were collected by the way of face -to- face questionnaire to patients or their guardians, consulting patient＇s medical record, checking physical or laboratory examination. Information included age, duration of the disease, the classification of antipsychotic, fast plasma glucose, plasma lipids, blood pressure etc of hospitalized schizophrenics. The diagnosis of MS was established with the criteria of branch of diabetes mellitus of Chinese Medical Association. Results： Among 602 schizophrenics, there were 214cases （ 35.5 % ） suffered from metabolic syndrome. Single - factor analysis showed that age, sex, duration of the disease, the classification of antipsychotic, etc, were at high risk of metabolic syndrome. Those schizophrenics suffered from metabolic syndrome the inpatient＇s scores of 3 dimensions and 10 factors of GQOL I - 74 were significantly lower than those of normal controls. Conclusions： The metabolic syndrome is highly prevalent among patients with schizophrenia and is strongly associated with female, oddly, longer duration of schizophrenia and clozapine etc. Those suffered from metabolic syndrome have lower physical, mental and social function, which is possibly associated with physical condition.