肝素佐治儿童过敏性紫癜67例临床分析

A clinical analysis of heparin in adjuvant treatment of 67 children with henoch-schonlein purpura

目的:评价小剂量肝素钠辅助治疗过敏性紫癜(HsP)的临床效果。方法:将126例HSP患儿随机分成观察组67例和对照组59例,观察组在综合治疗基础上加用肝素钠50 U/(kg·d),1次/d,静脉滴注,7～14 d为一疗程。结果:观察组总有效率97.01%,显著高于对照组总有效率74.58%(P<0.01)。结论:小剂量肝素钠治疗过敏性紫癜尤其顽固性腹型紫癜,无明显不良反应,疗效可靠。

Objective：To evaluate the clinical effects of low-dose heparin in adjuvant treatment of henoch-schonlein purpura （HSP）. Methods： 126 cases were randomly divided into an observation group and a control group. To the observation group heparin was applied intravenously, 50 U/（kg · d）, qd, 7 to 14 days on the basis of routine comprehensive therapy. Results：The total efficiency of 97.01% in observation group was significantly higher than that of 74.58% in the control group （ P 〈 0.01 ）. Conclusions： Low-dose heparin in treatment of henoch-schonlein purpura, particularly of intractable abdominal purpura is effective and reliable without side effects.