酚妥拉明和多巴胺佐治新生儿寒冷损伤综合征疗效探讨

The adjuvant effect of phentolamine and dopamine in scleredema neonatorum

目的:探讨酚妥拉明联合多巴胺佐治新生儿寒冷损伤综合征的疗效。方法:将40例中、重度新生儿寒冷损伤综合征患儿采用抽签法随机分治疗组20例,对照组20例。两组基础治疗相同,治疗组加用酚妥拉明1 mg/kg,多巴胺5mg加入10%葡萄糖注射液30 mL静脉滴注或输液泵输入,2次/d,疗程3～5 d。观察两组症状体征恢复正常时间、显效率及总有效率、不良反应发生情况等。结果:治疗组显效率(50%)和总有效率(90%)均高于对照组(分别为25%、75%),但差异均无统计学意义(P>0.05)。治疗组精神、饮食、尿量、体温恢复及皮肤硬肿消失时间均较对照组缩短,差异有统计学意义(P<0.05)。结论:酚妥拉明和多巴胺佐治新生儿寒冷损伤综合征有效、安全,值得推广。

Objective：To study the effect of phentolamine and dopamine in scleredema neonatorum. Methods ：40 scleredema neonatorum were divided into treatment group and control group with 20 cases in each randomly. Routine therapy was performed in both groups and phentolamine （ 1 mg/kg） and doparnine （5 mg） were given in treatment group in addition. The time need to recover and the total effective rate were observed and recorded. Results： The excellence rate and total effective rate were higher in treatment group （ 50% and 90% respectively） than in control group （25% and 75% respectively） but there＇s no difference. The recovery time in treatment group were shorter than that of control group （ P 〈 0.05 ）. Conclusions ： Phentolamine and dopamine are effective and safe in treating seleredema neonatorum.