多西紫杉醇联合低剂量氟尿嘧啶持续静脉输注治疗中晚期食管癌的近期疗效观察

Docetaxel combined with low doses of 5-fluorouracil continuous intravenous infusion for treating patients with advanced esophageal carcinoma

目的观察国产多西紫杉醇联合低剂量氟尿嘧啶(5-Fu)持续静脉输注治疗中晚期食管癌的近期疗效和毒副反应。方法20例中晚期食管癌患者行此方案化疗,多西紫杉醇40mg/(m2.d),静脉滴注1h,第1,8天;5-Fu250mg/(m2.d),低剂量持续泵静脉输注24h,连用14d。以上方案每4周为1周期,2周期观察近期疗效和毒副反应。结果20例患者均可评价疗效,其中CR1例,PR10例,SD5例,PD4例,总有效率55.0%(11/20)。主要毒副反应为骨髓抑制,非血液学毒性轻微。结论多西紫杉醇联合5-Fu低剂量持续泵静脉输注治疗中晚期食管癌具有较好疗效,副反应轻,耐受性好。

Objective To observe the efficacy and toxicity of China-made docetaxel combined with low doses of 5-fluorouracil （5-Fu） intravenous continuous infusion in the treatment of advanced esophagus carcinoma. Methods Twenty patients with advanced esophagus carcinoma received docetaxel 40 mg（ m^2 · d） iv infusion for 1 hour on dayl and day 8 respectively, 5-Fu was given by 250 rag（ m^2 · d） continuous iv infusion for 24 h from dayl to day 14. Every 4 weeks was a cycle and every patient received at least 2 cycles of chemotherapy. Results All 20 cases treated with this regimen could be evaluated for objective response. One patient achieved complete response （CR）, 10 patients partial response （PR）, 5 patients stable disease （SD） ,4 patients progression of disease（PD）. Overall response rate was 55.0%. The major toxic reactions included bone marrow depression and other mild side effects. Conclusion Docetaxel combined with low doses of 5-Fu continuous iv infusion for 24 h is an effective and tolerable regimen for the treatment of advanced esophageal carcinoma. It is worthy of popularization for use.