OLF与LFP方案治疗晚期胃癌疗效分析

Efficacy of OLF and LFP regimens in the treatment of advanced gastric carcinoma

目的观察草酸铂(L-OHP)联合甲酰四氢叶酸钙(LV)和氟尿嘧啶(5-Fu)组成的OLF方案及顺铂(DDP)联合甲酰四氢叶酸钙(LV)和氟尿嘧啶(5-Fu)组成的LFP方案治疗晚期胃癌的疗效及毒副作用。方法OLF组38例:L-OHP130mg/m2,静滴,0～3h,第1天;LV150mg/m2,静滴,0～2h,第1～5天;5-Fu500mg/m2,静滴,4h,第1～5天。LFP组42例:DDP30mg/m2,静滴,第1～3天;LV150mg/m2,静滴,0～2h,第1～5天;5-Fu500mg/m2,静滴,4h,第1～5天。以上方案均为每3周重复。结果OLF组和FLP组的有效率分别为62.6%和38.1%(P<0.05),中位疾病进展时间(timetoprogression,TTP)分别为28周和22周(P<0.05)。结论OLF方案治疗晚期胃癌较FLP方案疗效明显提高,延长了患者无病生存期,并改善了患者生活质量。

Objective To evaluate the response and major adverse reaction of OLF regimen [ oxaliplatin （L-OHP） ＋ calcium folinate （LV） ＋ 5-fluorouracil （ 5-Fu ） ] and LFP regimen [ cisplatin （ DDP ） ＋ LV ＋5-Fu] in the treatment of advanced gastric carcinoma. Methods Thirty-eight cases of advanced gastric carcinoma were treated with OLF regimen（L-OHP 130 mg/m^2 iv gtt 0-3h,d1 ;LV 150 mg/ m^2 iv gtt 0-2 h, d1-d5 ;5-Fu 500 mg/ m^2 iv gtt 4 h,d1-d5 ）. The other 42 cases were treated with FLP regimen（ DDP 30mg/ m^2 iv gtt 4 h ,d1 -d3 ;LV 150 mg/m^2 iv gtt 0-2 h,d1-d5 ; 5-Fu 500 mg/m^2 iv gtt 4 h,d1-d5 ）. Both regimens were repeated every three weeks. Rusults The overall response rates of the OLF group and LFP group were 62.6% and 38.1% respectively. The time to progression（TIP） was 28 weeks and 22 weeks respectively（ P 〈 0.05）. Conclusion In contrast to the FLP group, OLF regimen was more effective in the treatment of advanced gastric carcinoma with a longer survive time and better quality of life.