血浆Visfatin与2型糖尿病颈动脉粥样硬化的关系

THE RELATIONSHIP BETWEEN PLASMA VISFATIN AND CAROTID ATHEROSCLEROSIS OF TYPE 2 DIABETES MELLITUS

目的探讨血浆内脏脂肪素(visfatin)水平与2型糖尿病(T2DM)患者发生动脉粥样硬化的关系。方法采用酶联免疫吸附法测定T2DM患者和正常人空腹血浆visfatin水平,并在伴或不伴颈动脉粥样硬化的T2DM患者及正常对照组之间比较。结果T2DM组的空腹血浆visfatin水平均显著高于正常对照组(P均<0.05);伴颈动脉粥样硬化T2DM组空腹血浆visfatin水平明显高于不伴颈动脉粥样硬化T2DM组(P<0.05)。多元逐步回归分析表明:血浆visfatin水平升高主要受代谢综合征构成成份累积的影响而Logistic回归则显示动脉粥样硬化会受到代谢综合征的构成成分、C反应蛋白和visfatin的影响并且与颈动脉粥样硬化(AC)密切相关。结论visfatin可能与T2DM颈动脉粥样硬化的发生和发展相关。

Objective To explore the relationship between plasma visfatin level with atherosclerosis of T2DM Methods Fasting plasma visfatin levels were assayed by enzyme-linked immunosorbent assay（ELISA）,A comparison was made between groups of T2DM with or without carotid atherosclerosis and controls.Results The level of fasting visfatin in T2DM was significantly higher than controls（P〈0.05）.Fasting plasma visfatin level in T2DM with carotid atherosclerosis was significantly higher than without carotid atherosclerosis（P〈0.05）.Stepwise regression and logistic regression analysis indicated that accumulated ingredient of metabolic syndrome was a key factor which influenced on increasingly plasma visfatin level,plasma visfatin level was significantly correlated with carotid atherosclerosis.Conclusion Visfatin may contribute,in part,to the pathogenesis of carotid atherosclerosis of T2DM.