CD44v6、VEGF、CEA水平检测对良恶性胸腔积液鉴别的意义

THE DIAGNOSTIC VALUE OF CD44v6,VEGF and CEA IN DET ERMINATION of BENIGN or MALIGNANT PLEURAL EFFUSION

目的探讨CD44v6、VEGF、CEA单项和联合检测对鉴别良恶性胸腔积液的价值。方法选取70名胸腔积液患者,其中良性疾病组患者35例,恶性疾病组患者35例。采用ELISA法检测胸腔积液CD44v6、VEGF、CEA水平。结果在恶性疾病组中,CD44v6、VEGF、CEA的平均检测值分别为(45.50±24.94)ng/m、l(458.66±194.26)pg/m l和(29.92±20.57)ng/m l,在良性疾病组中CD44v6、VEGF、CEA平均检测值分别为(13.64±10.75)ng/m、l(137.88±73.72)pg/m、l(10.56±9.33)ng/m。l在单项检测中CD44v6、VEGF、CEA的敏感度分别为85.7%、91.4%、80.0%,特异度分别为80.0%、85.7%、71.4%;在联合检测中,VEGF+CD44v6组的敏感度为81.4%,特异度为90.0%;CD44v6+CEA组敏感度为68.6%,特异度为91.4%;VEGF+CEA组的敏感度为72.9%,特异度为94.3%;VEGF+CD44v6+CEA组敏感度为62.9%,特异度为96.2%。结论恶性疾病组胸腔积液CD44v6、VEGF、CEA水平分别明显高于良性疾病组,差异有显著性。单项检测中,VEGF和CD44v6有较高的敏感度和特异度,而在联合检测中,以VEGF+CD44v6和VEGF+CEA的敏感度和特异度相对较高。

Objective To observe the diagnostic value of CD44v6,VEGF and CEA in determination of benign or malignant pleural effusion.Methods Among 70 patients with pleural effusion,35 patients suffered from benign disease and 35 patients suffered from malignant disease.The expressions of CD44v6,VEGF and CEA in pleural effusion were detected with ELISA technique.Results In the group of malignant diseases,the average value of CD44v6,VEGF and CEA were 45.50 ±24.94ng/ml,458.66±194.26pg/ml and（29.92±20.57） ng /ml,respectively.In the group of benign disease,the average value of CD44v6,VEGF and CEA were 13.64±10.75ng/ml,137.88±73.72pg/ml and 10.56±9.33ng/ml,respectively.In single determination,the sensitivity of CD44v6,VEGF,CEA were 85.7%,91.4% and 80%,respectively.The specificity were 80%,85.7% and 71.4%,respectively,In combined determination,the sensitivity of VEGF＋ CD44v6 was 81.4%,and the specificity was 90.0%,The sensitivity of CEA ＋VEGF was 72.9% and the specificity was 94.3%,The sensitivity of CEA＋ CD44v6 was 68.6%,the specificity was 91.4%,The sensitivity of VEGF＋CD44v6＋CEA was 62.9%,the specificity was 96.2%.Conclusion The value of CD44v6,VEGF and CEA in malignant disease group is higher than that in benign disease group.There showed significant difference.In single detection,VEGF and CD44v6 have higher sensitivity and specificity.In combined detection,the groups of VEGF ＋ CD44v6 and VEGF＋CEA have higher sensitivity and specificity.