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细胞粘附分子在肿瘤骨转移中的作用 被引量：3

Role of cell adhesion molecules in bone metastasis of tumor
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摘要 骨转移是恶性肿瘤最常见的并发症之一。细胞粘附分子主要包括钙粘附素家族、整合素家族、选择素家族、免疫球蛋白超家族和透明质酸粘素(如CD44)等五类,通过同质型粘附和异质型粘附,在肿瘤骨转移中发挥作用。在治疗和预防肿瘤骨转移中,针对CAMs介导的抗粘附治疗将会是一种新的治疗方法。 Bone metastasis is one of the most common complications of malignant tumors.Cell adhesion molecules（CAMs）,including cadherin family,integrin family,selectin family,immunoglobulin superfamily,and hyaladherin,play an important role in bone metastasis of tumor through homotypic and heterotypic adhesive interactions.In this review,molecular and cellular mechanisms underpinning bone metastasis associated with CAMs,the role in a multi-step bone metastatic cascades will be discussed.
作者 牛晓敏(综述) 张杰(审校) 陆舜(审校)
机构地区 上海市胸科医院肺部临床肿瘤医学中心 复旦大学附属肿瘤医院胸外科
出处 《中国癌症杂志》 CAS CSCD 2008年第5期393-398,共6页 China Oncology
基金 上海市科委(基础研究)项目(072RP29) 中国博士后基金(20070410733) 复旦大学附属肿瘤医院影像学基金(YX200602)
关键词 细胞粘附分子 肿瘤细胞 骨转移 cell adhesion molecules tumor cells bone metastasis
分类号 R73-37 [医药卫生—肿瘤]
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参考文献31

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中国癌症杂志
2008年 第5期

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