期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

酒精依赖相关基因的遗传多态性 被引量：12

Genetic polymorphism for genes of alcohol dependence
下载PDF
导出
摘要 酒精依赖综合征受到复杂的生理、心理、个体遗传及环境等诸多因素的影响。有关研究已经证实了某些候选基因和酒精依赖密切相关。文章主要对与酒精依赖相关的酒精代谢关键酶(乙醇脱氢酶和乙醛脱氢酶以及细胞色素P450 2E1)基因以及调节神经递质作用的酶和受体(儿茶酚氧位甲基转移酶,多巴胺受体D2、D4,μ阿片受体)基因遗传多态性研究作一综述。 Alcohol dependence is a complex disorder which is influenced by physiological, psychological, environmental factors, individual inheritance and so on. Several candidate genes associated with alcohol dependence risk have been identified. The review focuses on several related genes that control alcohol metabolism such as alcohol dehydrogenase, aldehyde dehydrogenase, cytochrome P450 2E1 and regulate neurotransmission such as catechol-O-methyltransferase, dopamine receptors D2 and D4, and mu opioid receptor.
作者 贺艮峰 钟树荣 景强
机构地区 昆明医学院法医学院
出处 《遗传》 CAS CSCD 北大核心 2008年第4期413-418,共6页 Hereditas（Beijing)
基金 云南省自然科学基金项目(编号:2007C223M)资助~~
关键词 酒精依赖 遗传 基因 多态性 alcohol dependence heredity gene polymorphism
分类号 R749.6 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献47

  • 1Jee SH,Ohrr H,Sull JW,Samet JM.Cigarette smoking,alcohol drinking,hepatitis B,and risk for hepatocellular carcinoma in Korea.J Nat Cancer Inst,2004,96(24):1851-1856.
  • 2Hines LM.Genetic modification of the effect of alcohol consumption on CHD.Proc Nutr Soc,2004.63(1):73-79.
  • 3Prescott CA,Kendler KS.Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins.Am J Psychiatry,1999,156(1):34-40.
  • 4Kendler KS,Prescon CA,Neale MC,Pedersen NL.Temperance board registration for alcohol abuse in a national sample of Swedish male twins,born 1902 to 1949.Arch Gen Psychiatry,1997,54(2):178-184.
  • 5Eng MY,Schuckit MA,Smith TL.The level of response to alcohol in daughters of alcoholics and controls.Drug Alcohol Depend,2005,79(1):83-93.
  • 6Murphy JM,Stewart RB,Bell RL,Badia-Elder NE,Cart LG McBride WJ,Lumeng L,Li TK.Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference.Behav Genet,2002,32(5):363-388.
  • 7罗怀容,张亚平.乙醛脱氢酶2(ALDH2)基因研究进展及其与饮酒行为的关系[J].遗传,2004,26(2):263-266. 被引量：47
  • 8张行海.乙醇的代谢及毒性机理[J].湖北省卫生职工医学院学报,1998(2):50-52. 被引量：5
  • 9Ma L,Xue Y,Liu Y,Wang Z,Cui X,Li P,Fu S.Polymorphism study of seven SNPs at ADH genes in 15 Chinese populations.Hereditas,2005,142(2005):103-111.
  • 10Li TK,Yin SJ,Cmbb DW,O'Connor S,Ramchavdani VA,Genetic andenvironmentalinfluenceson alcoholmetabolism in humans.Alcohol Clin Exp Res,2001,25(1):136-144.

二级参考文献55

  • 1Mendenhall M.Disulfiram-induced fulminant hepatic failure in an active duty solider. Military Medicine,2004,169 (8):671-672.
  • 2Bowirrt A,Oscar-Berman M.Relationship between dopaminergic neuroWansmission, alcoholism, and reward deficiency syndrome. American Journal of Medical Genetic,2004,29(10):456-478.
  • 3Kenna GA. Aripiprazole, a new drug for alcohol abuse.Drug Future,2003,28( 12): 1227-1235.
  • 4Burris KD, Molski TIc, Xu C, et al. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptor. Journal of Pharmacology Experimental Therapy,2002,302(l):381-389.
  • 5Shapiro DA, Renock S, Arrington E, et al. Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology.Ncuropsychopharmacology,2003,28 (8):1400- 1411.
  • 6Li Z, Ichikawa J, Dai J, et al. Aripiprazole, a novel antipsychotic drug, preferentially increases dopamine release in the prefrontal cortex and hippocampus in rat brain. Europe Journal of Pharmalogy,2004,493(1-3):75-83.
  • 7Jordan S, Koprivica V, Dunn R, et al. In vivo effects of aripiprazole on cortical and striatal dopaminergic and serotonergic function. Europe Journal of Pharmacology,2004,483(1):45-53.
  • 8Swaninston Harrison T, Perry CM. Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. Drugs,2004,64(l 5): 1715-1736.
  • 9Mallikaarjun S, Salazar DE, Bramer SL Pharmacokinetics, tolerability, and safety of aripiprazole following multiple oral dosing in normal healthy volunteers. Journal of Clinical Pharmacology,2004,44(2): 179-187.
  • 10Cheng T A. Epidemiology of alcoholism among four aboriginal groups in Taiwan. Proceedings of the Symposium on Drink and Health Problems among Aboriginal Groups in Taiwan,1993,9-19.

共引文献87

同被引文献198

引证文献12

二级引证文献48

遗传
2008年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部