105例老年晚期非小细胞肺癌患者的回顾性分析

A retrospective analysis of 105 elderly patients with advanced non-small cell lung cancer

目的:研究老年晚期非小细胞肺癌(NSCLC)的临床特点,对化疗的耐受性和疗效。方法:回顾性分析2000年1月～2006年12月于中山大学肿瘤防治中心内科接受一线化疗的年龄≥70岁的晚期NSCLC(ⅢB或Ⅳ期)患者105例。结果:105例老年晚期NSCLC患者化疗有效率32.4%(34/105),中位生存期10.0个月(95%置信区间:6.6～13.4个月),35.2%(37/105)患者出现化疗相关的3～4级骨髓抑制,8.6%(9/105)患者出现3～4级消化道反应,全组患者未出现化疗相关死亡。结论:化疗对老年晚期NSCLC患者疗效好,毒性反应能耐受,对于有较好体力状态和器官功能的老年晚期NSCLC患者可以考虑给予标准含铂联合方案化疗。

Objective：To investigate the clinical characteristic and the efficacy and tolerability of chemotherapy in elderly patients with advanced non-small cell lung cancer.Methods：One hundred and five elderly patients（age≥70）with advanced non-small cell lung cancer（stage ⅢB or Ⅳ）were retrospectively analyzed.All these patients were first-line treated in the medical oncology department of cancer center of Sun Yat-Sen University from January 2000 to December 2006.Results：The response rate for all 105 patients was 32.4%（34/105）,with a median survival of 10.0 months（95% confidence interval,6.6 to 13.4 months）.There was a 35.2%（37/105）incidence rate of grade 3-4 myelosuppression and 8.6%（9/105）incidence rate of grade 3-4 gastrointestinal reaction in the 105 patients.No chemotherapy related death had been observed.Conclusion：Chemotherapy of elderly advanced NSCLC patients can produce a good efficacy and acceptable toxicity.Elderly patients with good performance status and organ function should be considered of treating with standard platinum-containing combination chemotherapy.