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趋化因子受体CCR7及其配体在肿瘤侵袭和转移中的研究进展 被引量:1

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摘要 趋化因子是一组由组织细胞和炎性细胞产生的、能够趋化细胞定向移动的小分子分泌蛋白,由70至100个氨基酸组成。迄今已发现50余种人的趋化因子,且在趋化因子中都有4个保守的半胱氨酸(C)。根据靠近氨基端(N端)的前两个C间是否插入其他的氨基酸,将他们分为四个亚型:CXC类、CC类、C类、CX3C类。一般认为,CXC类趋化因子主要作用于中性粒细胞,而CC、C和CX3C类趋化因子主要作用于单核/巨噬细胞及淋巴细胞。
出处 《中华病理学杂志》 CAS CSCD 北大核心 2008年第6期413-415,共3页 Chinese Journal of Pathology
基金 国家自然科学基金资助项目(30470667)
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