小青龙汤治疗支气管哮喘急性发作期临床研究

Clinical Research on Xiaoqinglong Decoction in Treating Acute Bronchial Asthma

目的:探讨小青龙汤治疗支气管哮喘发作期的临床疗效和安全性。方法:将40例支气管哮喘急性发作期患者随机分为小青龙汤组和西医常规治疗组,给药1周后,评价两组患者的病情、证候积分、外周血嗜酸粒细胞计数、肺功能改善及安全性情况。结果:小青龙汤和西医常规治疗相比,疾病临床疗效、证候积分、外周血嗜酸粒细胞计数、肺功能改善无显著性差异(P>0.05);但两组治疗后主要症状喘息、哮鸣音、胸闷、咯痰单项计分比较有显著性差异(P<0.05),小青龙汤组优于西药对照组。两组均未见不良反应。结论:小青龙汤治疗哮喘急性期有较好疗效,尤其对哮喘主要症状喘息、哮鸣音、胸闷、咯痰的改善方面具有优势,且用药安全。

Objective：To discuss the efficacy and safety of Xiaoqinglong decoction in treating acute bronchial asthma. Methods： 40 patients with acute bronchial asthma were randomly divided into Xiaoqinglong decoction group and the conventional western medicine group. The disease condition , the syndrome integral, the blood eosinophil count , the improvement of pulmonary function and the safety of medication were evaluated in both group after the theray for a week. Results：There had no significant difference among the effective rates of the two groups（P 〉 0.05）, there had significant difference among the accumulated score of the major TCM symptoms and physical sign（gasping ; wheezing ; chest distress; expectoration） of the two groups after and before treatment （P 〈 0.05）, this indicates that Xiaoqinglong decoction had a better curative effect on improving symptoms than the conventional western medicine group. The side-effect was not observed in both group. Conclusion：This indicates that Xiaoqinglong decoction effective in treating acute out- break of BA. Especially, the Xiaoqinglong decoction＇s effect on the gasping,wheezing,chest distress and expectoration were better than compared group. And this indicates the therapies in both groups are safe.