摘要
目的:合成奥沙拉秦。方法:以水杨酸为原料,在超声波作用下合成目标化合物。结果与结论:总收率为31.2%,反应时间为4.5h,与文献相比提高了产率,缩短了反应时间。
Objective:To synthesize olsalazine [3,3' -azobis (6-hydroxybenzonic acid) disodium] using ultrasound. Methods: Olsalazine was synthesized from salicylic acid using a new method of ultrasound. Results and conclusion: Using this new method, the yield of olsalazine was 31.2% and the reaction time was 4.5 h. In comparison with reported methods, the new method can yield more, needs shorter time, and is easier to control, which is feasible to prepare olsalazine.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2008年第10期858-860,共3页
Chinese Journal of New Drugs
关键词
奥沙拉秦
超声波
水杨酸
olsalazine
ultrasound
salicylic acid