克林霉素致急性喉水肿2例

Treatment of 2 patients with clindamycin-induced acute edema of larynx

目的:了解克林霉素用药罕见的不良反应,提高用药的安全性。方法:报告2例应用克林霉素后出现吸气性呼吸困难的患者的临床资料,进行分析。结果:克林霉素致急性喉水肿2例,1例给予停药、激素治疗及吸氧治疗后治愈;另1例急性会厌炎患者,应用克林霉素后突然出现呼吸困难、窒息,抢救无效死亡。结论:克林霉素可致急性喉水肿,急性会厌炎患者应慎用。

Objective： To uncover the rare adverse side effects of clindamycin and improve its safety in clinical applications. Methods： Report and analyze the clinical data of two patients with inspiratory dyspnea caused by clindamycin injection. Results： Clindamycin caused two cases of acute edema of larynx. In one case, the patient recovered after stopping clindamycin injection and receiving the hormone and oxygen treatment. In the other, the patient with acute epiglottitis suddenly experienced breathing difficulty and suffocation after clindamycin application, and died after unsuccessful rescue efforts. Conclusion： Clindamycin can cause acute edema of larynx and its use on acute epiglottitis patients should be cautious.