Raf蛋白激酶与肿瘤关系的研究进展

The Relationship of Raf-1 Kinase with Tumors

Raf蛋白激酶是由Raf基因编码的蛋白产物,Raf激活的机制可能是多层次、多种因素相互作用的结果。被激活的Raf蛋白的过表达与细胞生长、细胞周期停滞甚至与凋亡有关。Raf突变在多种恶性肿瘤中被探测到,因此是肿瘤介入治疗的重要靶点。Raf的异常表达也影响着肿瘤细胞耐药性的产生。一些Raf阻断剂正在临床试验中,因特定Raf基因过表达而发生的恶性肿瘤很可能会对raf蛋白的阻断剂敏感。RNAi干扰技术在抗肿瘤治疗中的广泛应用为我们寻找能更有效降低Raf活性的方法提供了新的途径。

Raf kinase is a protein coded by Raf gene, the activation of which is a complex process. Overexpression of activated raf proteins is associated with such divergent responses as cell growth, cell cycle arrest or even apoptosis. The mutation of Raf can be detected in many human cancers, so it was important target for therapeutic intervention. In certain cancer types, overexpression of Raf would induce drug resistance. Raf inhibitors have been developed and some are being evaluated in clinical trials. Some malignant tumors which overexpress a particular Raf gene may be more sensitive to inhibitor which targets that particular Raf protein. RNAi widely used in human cancer therapy might provide us a new way to inhibit the expression of Raf.