洛伐他汀对3种肺癌细胞株增殖的抑制作用

Inhibition of proliferation by lovastatin in three kinds of lung cancer cell lines

目的:观察洛伐他汀对肺癌细胞体外增殖的抑制作用。方法:采用MTT法,观察不同浓度的洛伐他汀分别作用24、48、72h对3种人肺癌细胞(A549,NCL-H460,PGCL3)生长增殖的影响。结果:洛伐他汀用药24、48、72h对3种肺癌细胞的生长增殖均有不同程度的抑制作用。洛伐他汀作用72h对3种肺癌细胞株(A549,NCL-H460,PGCL3)的IC50分别是39.6、28.3、35.6μmol/L。结论:洛伐他汀能有效抑制肺癌细胞的体外增殖,并且呈时间依赖性和浓度依赖性。

Objective：To observe the inhibition effect of lovastatin on proliferation of three kinds of lung cancer cell lines in vitro.Methods： After treatment of lung cancer cell lines （A549, NCL-H460 and PGCL3） with various concentration lo-vastatin for 24, 48, and 72 hours, the proliferation capacity of cells was observed by MTT.Results： After treated with lovastatin, the proliferation of these lung cancer cell lines were inhibited differently.The IC50 treated after 72 h of A549, NCL-H460, PGCL3 was 39.6,28.3,35.6 μmol/L.Conclusion： Lovastatin could inhibit the proliferation of lung cancer cells effectively in a time-and dose-dependent manner.