槲皮素对糖尿病性周围神经病变治疗的实验研究

The therapeutic action of quercetin on the painful diabetic peripheral neuropathy

目的:验证醛糖还原酶抑制剂槲皮素对糖尿病性周围神经病变的治疗作用。方法:Wistar大鼠180只(雌雄各半),首先随机取160只大鼠,采用四氧嘧啶腹腔注射建立糖尿病大鼠模型,测定模型组大鼠血糖及神经传导速度、痛觉潜伏期,余20只健康大鼠作为正常对照组。将模型组随机分成8组,第8组作为模型对照组,第1～6组分别喂服不同剂量槲皮素,第7组喂服阳性药物。灌服50d后测定各组痛觉潜伏期及神经传导速度。结果:第5、6模型组与模型对照组给药前后在神经传导速度方面比较,有非常显著性差异(P<0.01);第4组与模型对照组在痛觉潜伏期方面比较,有显著性差异(P<0.05);第5、6组与模型对照组在痛觉潜伏期方面比较,有显著性差异(P<0.01)。结论:槲皮素有较强的改善四氧嘧啶所致糖尿病大鼠周围神经病变的作用。

Objective：To verify the therapeutic action of the aloes reduction enzyme inhibitor quercetin on the painful diabetic peripheral neuropathy caused by alloxan.Methods：180 Wistar rats were randomly divided into diabetic group and controlled group.160 rats comprise of the diabetic group,of which the glucose level , nerve conducting rate （NCR）and pain latent period （PLP）were measured. The left 20 rats were taken as the controlled group.The diabetic group was again randomly divided into 8 groups. Groups 1 to 6 were given quercetin of different dose respectively. Group 7 was treated with positive drugs, and group 8 was left as diabetic controlled group. The PLP and NCR of all groups were measured on the 50th day after administration. Results： Compared with the diabetic controlled group after administration,group 5 and group 6 showed significant difference in PLP and NCR （P〈0.01）,and group 4 was comparatively different in PLP （P〈0.05）. Condusion：Quercetin has an excellent effect on painful diabetic peripheral neuropathy caused by alloxan.